Diagnostic Platforms

Detection chips based on microfluidics and surface modification achieved by Plasma Nanotechnology.

Detection Method

A simple color change initiated by an isothermal amplification reaction of genetic material.


Nanoplasmas holds the exploitation rights of 4 patents on plasma nanotechnology and 1 patent for the Legionella detection kit.

Plasma Nanotechnology

Nanoplasmas owns a pioneering technology for the modification of surfaces commonly used in diagnostics devices that leads to added-value products. The technology is called “plasma nannotechnology”, it is patented, and it is the result of more than ten years of research funded by several national and EU projects.

The company has incorporated this technology into microfluidic devices creating lab on chip diagnostic kits.

Nanoplasmas has several other products in the pipeline based on its innovative plasma nanotexturing technology. plasma Nanotechnology offers one step structural and chemical modification of materials. In this way, Nanostructures in the form of cones, columns, or fibers random or quasi ordered with predesigned chemistry are produced. Using plasma nanotechnology the wettability can be tuned and nanotextured surfaces that are water, ice, oil, and microorganism repellent (i.e. superaphiphobic, anti-icing, antifouling) and thus self-cleaning can be produced. Additionally, hydrophilic surfaces with increased biomolecule attraction and binding or antifogging properties can also be fabricated.


The analysis Is done on a hand held, easy to use microfluidic chip specifically designed for naked eye detection of pathogens.

Molecular based detection method

An in situ specific DNA amplification and chromogenic detection method is used. This method allows optical (visual) detection and decision on the presence of the pathogen with high sensitivity

Research projects

  • Legionella spp. diagnosis in 2 hours: A lab-on-a-chip for rapid, colorimetric detection in water-LEGEND
    Duration: 29/09/2020-28/09/2023
    The project “LEGEND” has been co‐financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code: T2EDK-03877

Smart Nanostructured Surfaces, Dr. Evangelos Gogolides

Dr. Evangelos Gogolides, co-founder of Nanoplasmas and research director in NCSR Demokritos, holder of 8 patents and author of many publications, talks about nanostructured surfaces. He explains in simple terms what nanotexturing is -a term they coined- and how plasma nanotechnology tunes surface properties. Interviewed by Vicki Kolovou for Tech Talks Central.

Selected Recent Publications/Conference Presentations


Lab on-Chip for Bacteria Capture, Lysis and DNA Amplification Addressing Foodborne Pathogens, Katerina Tsougeni, Georgia Kaprou, Angeliki Tserepi, Evangelos Gogolides, MNE 2017, Braga Portugal, Sep 18-22
Plasma micro-nanotextured 3D surfaces and their applications in wetting and life sciences, K. Ellinas, K. Tsougeni, D. A. Kanioura , D. Kefallinou, K. Stamatakis, P.S. Petrou, A. Tserepi, S.E. Kakabakos, E. Gogolides, EUROMAT 2017, Thessaloniki 17-22 September 2017
Plasma micro-nanotextured 3d surfaces and their applications on wetting control and biomolecule binding, K. Ellinas, K. Tsougeni, P.S. Petrou, A. Tserepi, S.E. Kakabakos , E. Gogolides, 31st SMT conference in Mons Belgium
Is There a Threshold in the Antibacterial Action of Superhydrophobic Surfaces? , Ellinas, K. Kefallinou, D. Stamatakis, K. Gogolides, E. Tserepi, A., ACS Appl. Mater. Interfaces, 9 (45), pp 39781–39789,(2017).


3D Plasma Nanotextured® Polymeric Surfaces for Protein or Antibody Arrays, biomolecule and Cell Patterning, Katerina Tsougeni, Kosmas Ellinas, George Koukouvinos, Panagiota S. Petrou, Angeliki Tserepi, Sotirios E. Kakabakos, and Evangelos Gogolides, , Methods in Molecular Biology, 1771, pp. 27-40 Springer.
3D Plasma Nanotextured slides performance for biomolecule microarrays: Comparison with commercially available coated glass slides, Katerina Tsougeni, Kosmas Ellinas, George Koukouvinos, Panagiota S. Petrou, Angeliki Tserepi, Sotirios E. Kakabakos, and Evangelos Gogolides, , Journal of Colloid and Interface Science, 165, 270-277, (2018).


A sensitive Lab-on-a-chip for pathogen detection using a simple colour-change DNA amplification reaction, Georgia Kaprou, Katerina Tsougeni, Athina Kastania, Christos-Moritz Loukas, Athanasios Smyrnakis, Kosmas Ellinas, Evangelos Gogolides, Angeliki Tserepi, 45th International Conference on  Micro & Nano Engineering, ΜΝΕ 2019
A modular integrated lab-on-a-chip platform for fast and highly efficient sample preparation for foodborne pathogen screening, K.Tsougeni, A.S.Kastaniaa, G.D.Kaprou, MichaelEckcGerhardJobst, P.S.Petrou, S.E.Kakabakos, D.Mastellos, E.Gogolides, A.Tserepi, Sensors & Actuators,  288, 171-179 (2019).


Fluorescence Enhancement on Silver-Plated Plasma Micro-Nanostructured 3D Polymeric Microarray Substrates for Multiplex Mycotoxin Detection by Georgios Koukouvinos, Chrysoula-Evangelia Karachaliou, Anastasia Kanioura, Katerina Tsougeni, Evangelia Livaniou, Sotirios Elias Kakabakos and Panagiota Sotirios Petrou Processes 2021, 9(2), 392;